Pharmacoscintigraphic evaluation and antidiabetic efficacy of gliclazide-loaded 99mTc-labelled mucoadhesive microspheres

Abstract Background The current study was carried out to evaluate the possible application of Musa balbisiana starch in formulation mucoadhesive microsphere for oral delivery gliclazide (GLZ). objective improve bioavailability along with prolongation its duration action a better glycaemic control. Ionic gelation technique employed formulating dosage form. Optimization batches by response surface methodology using 3 2 full factorial designs. prepared characterized several parameters vitro release study. gastrointestinal transit optimized batch microspheres after administration studied rabbits gamma scintigraphy utilizing 99mTc as labelling agent presence stannous chloride. Also, pharmacokinetic parameters. Moreover, antidiabetic efficacy evaluated rats streptozotocin (STZ)-induced diabetic model. Results design experiment resulted an optimum coded F8. compatible nature drug and excipient revealed from FTIR, DSC IST studies. scanning electron micrographs also showed occurrence spherical having smooth surface. provided evidence initial burst effect that followed prolong phase. justified ability form sustaining 2.7-fold enhancement bioavailability. images obtained during suggested gastro-retentive more than 4 h. pharmacodynamics rat model confirmed about lowering elevated blood glucose level. Conclusion overall data provide valuable information potential this banana can be used drug-like which turn beneficial management diabetes.